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Many men wonder about the safety of Testosterone Replacement Therapy (TRT), especially regarding hearthealth and prostate cancer. Here’s what current research and clinical guidelines show:
Cardiovascular Health and TRT
The TRAVERSE trial (NEJM, 2024) studied over 5,000 men with low testosterone. Results showed TRT did notincrease the risk of major cardiovascular events such as heart attacks or strokes. A 2024 meta-analysis inAndrology also concluded that TRT has neutral to beneficial effects on vascular health.
Prostate Cancer Concerns
Older beliefs suggested testosterone fuels prostate cancer. However, research (European Urology, 2009) showsthat once prostate tissue has enough testosterone, more does not increase cancer risk. Restoring testosterone tonormal levels is considered safe.
Metabolic Health Benefits
TRT may improve metabolic health, including insulin resistance, blood sugar control, cholesterol, and belly fat. AEuropean Journal of Endocrinology study (2006) showed improvements in men with low testosterone and type 2diabetes.
Guidelines
The American Urological Association supports TRT as a safe, effective treatment for men with confirmed lowtestosterone and symptoms, when properly monitored.
Key Takeaways
• TRT does not increase cardiovascular risk when prescribed appropriately.
• Research shows TRT does not cause prostate cancer.
• TRT may improve metabolic health, especially in men with type 2 diabetes or obesity.
• National guidelines support TRT as safe and effective when monitored.
At Reclaim Med Spa & Wellness, we provide evidence-based hormone therapy with a focus on safety andlong-term health. Ask us if TRT is right for you.
References
[1] TRAVERSE Investigators. Testosterone Treatment and Cardiovascular Outcomes. NEJM. 2024.[2] Morgentaler A, Traish AM. Shifting the Paradigm of Testosterone and Prostate Cancer: The Saturation Model.
European Urology. 2009;55(2):310–320.
[3] Cannarella R, et al. Testosterone Replacement Therapy and Vascular Outcomes: Systematic Review and
Meta-analysis. Andrology. 2024.
[4] Kapoor D, Goodwin E, Channer KS, Jones TH. TRT Improves Insulin Resistance, Glycemic Control, Visceral
Adiposity, and Hypercholesterolemia in Hypogonadal Men With Type 2 Diabetes. Eur J Endocrinol.
2006;154(6):899–906.
[5] American Urological Association. Guideline: Evaluation and Management of Testosterone Deficiency.y is right for you.
